Where can I find the primary clinical evidence?

Primary trials are published in peer-reviewed journals (NEJM, JAMA, Lancet) with PubMed PMIDs cited throughout GLP1 One Rx.

STEP Trial Results — Pivotal Weight-Loss Evidence

STEP Trial Results

Released: January 15, 2026Last reviewed: October 15, 2026

STEP-1 through STEP-4 trials established semaglutide's weight-management efficacy. Pivotal STEP-1 (NEJM 2021, PMID 33567185): 14.9% mean weight loss at 2.4 mg / 68 weeks.

Clinical referencePubMed-linkedUpdated 2026-05-25

Researched By

Dr. Parmis

Medical Researcher · Western University of Health Sciences

Medically Reviewed By

Dr. Jonathan Snipes, MD · Kim Callender, NP (FNP-BC)

Last medically reviewed: October 15, 2026 · This page is informational and does not constitute medical advice.

Overview

STEP-1 through STEP-4 trials established semaglutide's weight-management efficacy. Pivotal STEP-1 (NEJM 2021, PMID 33567185): 14.9% mean weight loss at 2.4 mg / 68 weeks.

PubMed citations

PMID 33567185

Related clinical pages

STEP trial results
SELECT trial results
FLOW trial results
Mechanism of action
Dosing & pharmacology
Contraindications
Side effects