Key facts
Mechanism of action
Coenzyme essential for cellular energy metabolism, DNA repair, and sirtuin activity. NAD+ levels decline with age. IV and SC NAD+ are used to restore cellular function; oral precursors (NR, NMN) are alternatives.
Standard dosing
Typical clinical use: 50-200 mg SC daily or 500-1000 mg IV weekly. Dosing varies by indication and provider protocol; this is reference-only and not a prescribing recommendation. NAD+ requires a prescription from a licensed clinician.
Regulatory status & pharmacy pathway
Not FDA-approved (compounded for SC/IV). Compounded peptides are dispensed via 503A licensed compounding pharmacies (USP <797> sterile compounding) or 503B FDA-registered outsourcing facilities (cGMP). Patients should request the pharmacy of record and certificates of analysis (USP <71> sterility, USP <85> endotoxin, HPLC potency) for every shipment.
U.S. telehealth providers prescribing NAD+
The most commonly cited U.S. telehealth providers for NAD+ are Defy Medical, Marek Health, Hone Health, Maximus, and PeterMD — all of which offer prescriber-supervised access with lab integration and 503A pharmacy partnerships. See the full provider directory for complete profiles.
Trade-offs to know
NAD+ carries the trade-offs common to all compounded peptide therapeutics: not FDA-approved (when applicable), cash-pay only, no in-network insurance coverage, and pharmacy-quality variation between providers. Choose a prescriber that publishes pharmacy of record, per-vial CoAs, and lab-integrated follow-up.
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Editorial team
Researched by Dr. Parmis (Editorial Lead); medically reviewed by Dr. Jonathan Snipes, MD and Kim Callender, NP (FNP-BC). About our team →