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Growth Hormone · GHRP

GHRP-2

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GHRP-2 is a synthetic growth hormone-releasing peptide (hexapeptide) that stimulates pituitary GH release through the ghrelin receptor. Used in research settings and by compounding pharmacies.

Category: Growth Hormone Secretagogues Last updated 2026-05-25
GHRP-2 at a glance

GHRP-2 is a synthetic growth hormone-releasing peptide (hexapeptide) that stimulates pituitary GH release through the ghrelin receptor. Used in research settings and by compounding pharmacies. Mechanism: GHRP / GH secretagogue. Typical route: Subcutaneous. FDA status: Not FDA-approved. Used in clinical research and dispensed by compounding pharmacies.

Drug classGHRP / GH secretagogue
Half-life~30 minutes
RouteSubcutaneous
Common dosing100-300 mcg, 2-3x/day
FDA statusNot approved
Available throughCompounding pharmacies

Mechanism of action

GHRP-2 binds the growth hormone secretagogue receptor (GHS-R1a, the ghrelin receptor) on pituitary somatotrophs, stimulating endogenous growth hormone release. Effects are most pronounced when combined with a growth hormone-releasing hormone (GHRH) analog such as CJC-1295.

Dosing reference

Subcutaneous: 100-300 mcg, two to three times daily, often combined with CJC-1295 1295 100 mcg per dose. Standard protocols dose on an empty stomach and around exercise or before bed.

Dosing information is provided for educational reference and is not medical advice. Patients should not initiate or modify any peptide regimen without consulting a licensed clinician. See our medical disclaimer.

FDA status & regulatory framework

Not FDA-approved. Used in clinical research and dispensed by compounding pharmacies.

U.S. telehealth providers that work with GHRP-2

Also covered
88/100May 2026 review (v3.0 rubric); v4.1 re-score pending

Starting at $160/mo. Defy Medical is one of the providers covered in our editorial directory that dispenses or coordinates GHRP-2.

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Also covered
85/100May 2026 review (v3.0 rubric); v4.1 re-score pending

Starting at $180/mo. Marek Health is one of the providers covered in our editorial directory that dispenses or coordinates GHRP-2.

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Also covered
76/100May 2026 review (v3.0 rubric); v4.1 re-score pending

Starting at $149/mo. Maximus is one of the providers covered in our editorial directory that dispenses or coordinates GHRP-2.

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Also covered
80/100May 2026 review (v3.0 rubric); v4.1 re-score pending

Starting at $149/mo. Hone Health is one of the providers covered in our editorial directory that dispenses or coordinates GHRP-2.

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Frequently asked questions about GHRP-2

How does GHRP-2 compare to GHRP-6?

GHRP-2 stimulates less appetite (less ghrelin-like effect) and is generally preferred when patients want GH stimulation without the increased hunger that GHRP-6 commonly causes.

Is GHRP-2 worth using with CJC-1295?

The combination (GHRP + GHRH analog) produces a larger and more sustained GH pulse than either alone. CJC-1295/Ipamorelin is a more commonly prescribed pairing today.

References

  1. Bowers CY. GH releasing peptides--structure and kinetics. J Pediatr Endocrinol. 1993;6(1):21-31. PMID: 8348220
  2. Bowers CY, Granda R, Mohan S, Kuipers J, Baylink D, Veldhuis JD. Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women. J Clin Endocrinol Metab. 2004;89(5):2290-2300. PMID: 15126555

Sources are peer-reviewed where available. PubMed (PMID) links resolve to NCBI's PubMed database. FDA links resolve to the U.S. Food and Drug Administration. Citations were last verified 2026-05-11.

Researched By
Dr. Parmis
Medical Researcher · Western University of Health Sciences
Medically Reviewed By
Dr. Jonathan Snipes, MD · Kim Callender, NP (FNP-BC)
Last medically reviewed: October 15, 2026 · This page is informational and does not constitute medical advice.